Participants must be knowledgeable about critical care nutrition, have Good Clinical Practice (or similar) training, and be committed to enrolling a minimum of 30 eligible patients in 2-3 years. Setting: ICUs from around the world will voluntarily participate and be screened for suitability. Study Design: A multicenter, pragmatic, volunteer-driven, registry-based, randomized, clinical trial. Overall Hypothesis: Compared to a control group reflective of usual care prescribing practices, the administration of a higher dose protein/amino acids to nutritionally high-risk critically ill patients will be associated with improved survival and a quicker rate of recovery. NOTE: If you have any questions please contact Jennifer Korol ( This email address is being protected from spambots. The specific purpose of the current proposal is to provide the rationale for a large clinical trial of 2 different protein doses that demonstrate the value of extra protein supplementation in critically ill, nutritionally high-risk patients using the INS as a type of RRCT.Ĭurrent Status: The study is no longer accepting new ICUs. Synopsis: In this project, we aim to combine the International Nutrition Survey (INS) with the power of randomization to conduct a registry-based randomized clinical trial (RRCT).
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